Evaluation of nitroglycerin in angina in patients on isosorbide dinitrate.
نویسندگان
چکیده
Seventeen male patients with angina pectoris due to coronary artery disease who had not received long-acting nitrites for at least 1 mo prior to this study were evaluated in a double-blind crossover study to investigate whether the presence of isosorbide dinitrate interfered with the effective response of exercise-induced angina to nitroglycerin administered sublingually. There was no significant difference in the duration of angina following nitroglycerin whether the patients were on no medication, sublingual placebo or sublingual isosorbide dinitrate. There was no significant difference in the blood pressure, heart rate, product of systolic blood pressure and heart rate,
منابع مشابه
Cost-effectiveness study of nitrate therapy using a decision analysis methodology.
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Twenty-one patients with documented coronary atherosclerotic heart disease were studied to determine the effect of high dose oral isosorbide dinitrate (ISDN) on heart rate, blood pressure, and exercise time until angina pectoris. Patients were tested in two phases, initially with 0.4 mg of sublingual nitroglycerin and with sublingual placebo, and then with oral ISDN, mean dose 29 mg, and oral p...
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عنوان ژورنال:
- Circulation
دوره 42 1 شماره
صفحات -
تاریخ انتشار 1970